Full
Outline
To evaluate the efficacy, safety, and economics of tirzepatide in the treatment of overweight/obesity.
A comprehensive comparison of the efficacy of tirzepatide and semaglutide in the treatment of overweight/obesity was performed using reticulated Meta-analysis (NMA), and cost-effectiveness analysis was used for pharmacoeconomic evaluation.
A total of 14 randomized controlled trials were searched. The NMA showed that for efficacy, the tirzepatide group was significantly better than the simelglutide group in terms of weight loss (MD=-6.50%, 95%CI: -8.13% to -4.87%), waist circumference reduction (MD=-5.40%), and the attainment rate of >15% weight loss (RR=1.28) (P<0.001), but the glycemic control was not statistically different. For safety, the overall incidence of gastrointestinal adverse events was similar in both groups, with a lower risk of vomiting with telbivudine (RR=0.70, 95%CI: 0.55~0.89). For the pharmacoeconomics, the ICER value of 87 714.55 yuan was well below the willingness-to-pay threshold, suggesting that tirzepatide was more cost-effective compared with semaglutide.
The weight loss efficacy and economy of tirzepatide are significantly better than those of semaglutide, and its long-term safety needs to be further verified in the future.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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