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In vitro release study of benzoyl peroxide gel
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Yi-xin CUI1, 2, 3, Xiao-xia YE2, 3, *, Jian LE2, 3, *
Chinese Journal of New Drugs | 2026, 35(13) : 1432 - 1439
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Chinese Journal of New Drugs | 2026, 35(13): 1432-1439
In vitro release study of benzoyl peroxide gel
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Yi-xin CUI1, 2, 3, Xiao-xia YE2, 3, *, Jian LE2, 3, *
Affiliations
  • 1School of Pharmacy, Fudan University, Shanghai 201203, China
  • 2Shanghai Institute of Food and Drug Inspection, Shanghai 201203, China
  • 3National Medical Products Administration Key Laboratory of Chemical Preparation Quality Analysis, Shanghai 201203, China
Published: 2026-07-15 doi: 10.20251/j.cnki.1003-3734.2026.13.013
Outline
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Objective:

To investigate the in vitro release behavior of benzoyl peroxide gel using a diffusion cell method, and to obtain release profiles with subsequent kinetic model fitting.

Methods:

The method was established with Franz diffusion cell. The PEG400-ethanol-water (25∶25∶50) is selected as receiving medium. The nylon membrane with 0.45 μm is used as the artificial membrane. The release amount was determined by high performance liquid chromatography (HPLC). The release data were fitted to zero-order, first-order, Korsmeyer-Peppas, and Higuchi models to identify the optimal release model.

Results:

An in vitro release testing method for benzoyl peroxide gel was successfully established. The release data of benzoyl peroxide were best fitted by the zero-order kinetic model, whereas the release data of benzoic acid were best described by the Higuchi model.

Conclusion:

The established in vitro release method is suitable for evaluating the release characteristics of benzoyl peroxide gel and provides a useful reference for the quality assessment of topical formulations containing poorly soluble drugs.

benzoyl peroxide gel  /  in vitro release test  /  consistency evaluation  /  diffusion cell  /  HPLC
崔潆心, 叶晓霞, 乐健. 过氧苯甲酰凝胶体外释放研究. 中国新药杂志, 2026 , 35 (13) : 1432 -1439 . DOI: 10.20251/j.cnki.1003-3734.2026.13.013
Yi-xin CUI, Xiao-xia YE, Jian LE. In vitro release study of benzoyl peroxide gel[J]. Chinese Journal of New Drugs, 2026 , 35 (13) : 1432 -1439 . DOI: 10.20251/j.cnki.1003-3734.2026.13.013
Appendix
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Year 2026 volume 35 Issue 13
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.13.013
  • Online Date：2026-10-26
  • Published：2026-07-15
Article Data
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History
  • Accepted：2025-10-27
Affiliations
    1School of Pharmacy, Fudan University, Shanghai 201203, China
    2Shanghai Institute of Food and Drug Inspection, Shanghai 201203, China
    3National Medical Products Administration Key Laboratory of Chemical Preparation Quality Analysis, Shanghai 201203, China
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https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.13.013
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表12种不同金属材料的力学参数
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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