Full
Outline
To design a coaxial drug-loaded composite fiber membrane with a core-shell structure. The coaxial drug-loaded fiber membrane was fabricated using electrospinning and electrospraying techniques, achieving satisfactory quality with demonstrated efficacy in promoting wound healing and antibacterial activity.
Physicochemical characterization, quality control, and in vitro and in vivo efficacy evaluation were conducted on the fabricated composite fiber membrane.
The coaxial nanofibers exhibited a distinct core-shell structure and excellent antibacterial efficacy. H&E staining and VEGF immunohistochemistry confirmed that the coaxial drug-loaded composite fiber membrane promoted collagen synthesis, accelerated neovascularization, and facilitated wound healing.
The prepared coaxial drug-loaded composite fiber membrane meets all the testing requirements and can effectively promote wound healing and inhibit bacteria, providing a new approach for the development of novel wound dressings.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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