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Outline
The incidence and mortality rate of non-small cell lung cancer (NSCLC) rank among the highest among malignant tumors globally. Currently, the management of NSCLC patients poses significant challenges in clinical practice, characterized by high postoperative complication mortality rates and substantial side effects from drug therapy. In recent years, nanomedicine approaches have emerged by providing efficient nano-drug delivery systems that precisely deliver anticancer drugs to cancer cells, overcoming the limitations of traditional chemotherapy to enhance NSCLC treatment efficacy. Furthermore, traditional Chinese medicine (TCM) demonstrates remarkable advantages in the prevention and treatment of NSCLC. Various TCM monomers, active components, and compound formulations enhance immunity, improve quality of life, and reduce NSCLC metastasis risk through multi-component, multi-target, and multi-pathway mechanisms. However, they face challenges such as poor water solubility, low bioavailability, and insufficient targeting specificity. Nano-delivery systems address these issues by enhancing the bioavailability and solubility of active TCM components while enabling precise targeting of cancer cells for efficient and accurate NSCLC treatment. Therefore, this article reviews the research progress in the synergistic treatment of NSCLC using TCM-nano strategies based on nano-delivery systems, while exploring their application prospects, aiming to develop new methods and approaches for NSCLC therapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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