Home Journals Articles Updates About
CN
image
收藏切换
Research progress in antibody-dependent enhancement of human immunodeficiency virus
收藏切换
Yu JIANG1, Ting-ting XU1, 2, Chen-jie LI1, Zhi-peng ZHANG1, Heng ZHANG2, Lu ZHOU2, Yun-liang QIU1, *
Chinese Journal of New Drugs | 2026, 35(12) : 1263 - 1269
Less
收藏切换
Chinese Journal of New Drugs | 2026, 35(12): 1263-1269
Research progress in antibody-dependent enhancement of human immunodeficiency virus
Full
Yu JIANG1, Ting-ting XU1, 2, Chen-jie LI1, Zhi-peng ZHANG1, Heng ZHANG2, Lu ZHOU2, Yun-liang QIU1, *
Affiliations
  • 1China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 2Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
Published: 2026-06-30 doi: 10.20251/j.cnki.1003-3734.2026.12.005
Outline
收藏切换

Antibody-dependent enhancement (ADE) refers to the phenomenon where certain non-neutralizing antibodies or sub-neutralizing concentrations of antibodies do not eliminate viruses during viral infection but instead promote viral invasion and replication. In human immunodeficiency virus (HIV) infection, it has been found that some antibodies can form immune complexes with the virus and mediate viral entry into target cells through Fc receptors (FcR) or the complement system, thereby exacerbating disease progression. In recent years, with the in-depth study of HIV infection, the ADE phenomenon has received extensive attention in the development and clinical application of HIV vaccines. This article reviewed the mechanism of ADE in HIV infection, the influencing factors of ADE occurrence, and the implications of ADE for drug development, and explored the impact and potential risks of ADE in HIV infection in depth, providing theoretical support for the development of safe and effective HIV vaccines and antibody drugs.

antibody-dependent enhancement  /  human immunodeficiency virus  /  receptor  /  vaccine safety  /  antibody therapy
姜宇, 徐婷婷, 李晨洁, 张智鹏, 张恒, 周璐, 邱云良. 人类免疫缺陷病毒的抗体依赖性增强作用研究进展. 中国新药杂志, 2026 , 35 (12) : 1263 -1269 . DOI: 10.20251/j.cnki.1003-3734.2026.12.005
Yu JIANG, Ting-ting XU, Chen-jie LI, Zhi-peng ZHANG, Heng ZHANG, Lu ZHOU, Yun-liang QIU. Research progress in antibody-dependent enhancement of human immunodeficiency virus[J]. Chinese Journal of New Drugs, 2026 , 35 (12) : 1263 -1269 . DOI: 10.20251/j.cnki.1003-3734.2026.12.005
Appendix
Less
Year 2026 volume 35 Issue 12
53
10
Cite this Article
BibTeX
Article Info
doi: 10.20251/j.cnki.1003-3734.2026.12.005
  • Online Date：2026-10-26
  • Published：2026-06-30
Article Data
Affiliations
History
  • Accepted：2026-03-21
Funding
Affiliations
    1China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    2Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
References
Share
https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.12.005
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House