Full
Outline
To mine the adverse events (AEs) related to bevacizumab in ovarian cancer patients from the FDA Adverse Event Reporting System (FAERS) and to reveal their clinical priority information, so as to provide a reference for clinical medication.
AE reports related to bevacizumab for ovarian cancer were collected from the FAERS database from the first quarter of 2004 (Q1) to the first quarter of 2025 (Q1). Signal mining was performed using the reporting odds ratio (ROR), proportional reporting ratio (PRR) and Bayesian Confidence Propagation Neural Network (BCPNN) methods, and clinical priority assessment of positive signals was conducted.
A total of 5 025 reports were include. Physicians were the primary reporters (60.23%), and the United States accounted for the largest proportion of reporters (36.16%). A total of 195 preferred term (PT) signals were identified, spanning 20 System Organ Classes (SOCs). General disorders and administration site conditions was the most frequently reported SOC. Common AEs included hypertension, proteinuria and neutropenia, etc. The median onset time of all AEs was 81 days. Clinical priority classification: 2 PTs were classified as strong priority, 62 PTs as moderate priority, and 131 PTs as weak priority. The strong priority PTs were intestinal perforation and gastrointestinal perforation.
Based on an extensive analysis of the post-marketing international safety database, this study identified common AEs associated with bevacizumab in ovarian cancer patients, and highlighted the need for close monitoring of intestinal perforation and gastrointestinal perforation, providing a reference for clinical medication and pharmacovigilance.
54
7
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
