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Outline
The rapid and sustained antidepressant effects of brexanolone and zuranolone represent a breakthrough in the treatment of postpartum depression (PPD) fueling in-depth research into the antidepressant mechanisms of gamma-aminobutyric acid type A receptor (GABAAR) modulators. This article systematically reviews 14 clinical trials, and evaluates the clinical advantages and potential limitations of brexanolone and zuranolone though post-hoc analysis, providing valuable insights for clinical application. Additionally, based on recent mechanistic studies of brexanolone and its analogs, three hypotheses are proposed to explain their rapid and lasting antidepressant effects: the neuroendocrine hypothesis, neural oscillation hypothesis, and neurotrophic factor hypothesis, offering novel directions for development of drugs for PPD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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