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Outline
This study employs cryo-electron microscopy (Cryo-EM) to precisely evaluate the physical stability of liposomes in situ. Cryo-EM eliminates the need for drying and staining, thereby preserving the native morphology of liposomes to the greatest extent. It clearly reveals the bilayer membrane structure and the spatial distribution of encapsulated substances, overcoming issues such as deformation, hydration layer interference, and probe convolution effects associated with traditional characterization methods. Cryo-EM enables efficient and intuitive assessment of liposome morphology, particle size, size distribution, and the state of encapsulated materials. Cryo-EM provides reliable scientific evidence and quality control standards for the development and optimization of liposomal formulations. Ultimately, it enhances the consistency and comparability of drug development and production, meeting the growing clinical demands.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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