Home Journals Articles Updates About
CN
image
收藏切换
Advances in surface-functionalized brain-targeted nano-drug delivery systems
收藏切换
Yu ZHANG1, Sheng-nan LU2, Jun-li ZHANG1, Yao-yao ZHANG3, Ling CHENG3, Jing LI3, Ying LI2, Feng SU1, 2, 3, *, Guang-wei HE1, 2, 3, *
Chinese Journal of New Drugs | 2026, 35(8) : 785 - 794
Less
收藏切换
Chinese Journal of New Drugs | 2026, 35(8): 785-794
Advances in surface-functionalized brain-targeted nano-drug delivery systems
Full
Yu ZHANG1, Sheng-nan LU2, Jun-li ZHANG1, Yao-yao ZHANG3, Ling CHENG3, Jing LI3, Ying LI2, Feng SU1, 2, 3, *, Guang-wei HE1, 2, 3, *
Affiliations
  • 1School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
  • 2Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
  • 3School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2026-04-30 doi: 10.20251/j.cnki.1003-3734.2026.08.001
Outline
收藏切换

Central nervous system (CNS) diseases have become a major global public health challenge. With the extension of human lifespan and the intensification of population aging, the incidence of these diseases has shown a significant upward trend, yet their clinical treatment still faces critical technological bottlenecks. The presence of the blood-brain barrier (BBB) hinders the delivery of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain, rendering conventional drug administration methods unable to achieve effective therapeutic concentrations. In recent years, brain-targeted nano-drug delivery systems based on nanotechnology have demonstrated breakthrough potential: nanocarriers can improve the efficiency of drug crossing the BBB through size effects; surface functional modifications enable precise drug delivery to the brain. This article describes the composition and function of the BBB, the types of nanocarriers, and brain-targeting strategies via functional group modifications, aiming to provide theoretical foundations and technical references for developing safe and efficient brain-targeted nano-drug delivery systems.

nano-drug delivery system  /  brain-targeting  /  functional group ligand  /  blood-brain barrier  /  nanocarriers  /  central nervous system
张宇, 鲁胜男, 张俊丽, 张瑶瑶, 程玲, 李静, 李颖, 苏峰, 何广卫. 功能基修饰的脑靶向纳米递药系统研究进展. 中国新药杂志, 2026 , 35 (8) : 785 -794 . DOI: 10.20251/j.cnki.1003-3734.2026.08.001
Yu ZHANG, Sheng-nan LU, Jun-li ZHANG, Yao-yao ZHANG, Ling CHENG, Jing LI, Ying LI, Feng SU, Guang-wei HE. Advances in surface-functionalized brain-targeted nano-drug delivery systems[J]. Chinese Journal of New Drugs, 2026 , 35 (8) : 785 -794 . DOI: 10.20251/j.cnki.1003-3734.2026.08.001
Appendix
Less
Year 2026 volume 35 Issue 8
47
7
Cite this Article
BibTeX
Article Info
doi: 10.20251/j.cnki.1003-3734.2026.08.001
  • Online Date：2026-10-26
  • Published：2026-04-30
Article Data
Affiliations
History
  • Accepted：2025-06-09
Affiliations
    1School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
    2Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
    3School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
References
Share
https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.08.001
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House