Full
Outline
Micron-scale tablets (1 000~3 000 μm), driven by the dual forces of Pharmaceutical Industry 4.0 and precision medicine, have emerged as a core carrier for pediatric and personalized treatment due to their exceptional dose flexibility and multi-unit delivery advantages. The quality by design (QbD) concept provides a systematic framework to overcome key industrialization bottlenecks-such as poor flowability at high drug loads, challenges in achieving blend uniformity for ultra-low-dose formulations, and stringent sensitivity requirements for miniaturized quality control-facilitating the successful establishment of a multidimensional "structure-process-quality" correlation model in the field. Research advances demonstrate that the integration of multimodal spectral imaging (HSI-FT-NIR coupling) with neural network fusion technology enables real-time tracking of content uniformity and release profiles at the millimeter level, facilitating the formation of a full-chain quality control closed-loop from process analysis to dynamic release. The integrated application of innovative technologies such as hot melt extrusion-based microfluidic 3D printing offers new pathways for constructing complex functional dosage forms like colon-targeted and gastric-floating tablets. This review further examines the challenges and breakthrough directions for intelligent upgrades in continuous manufacturing under the QbD framework and outlines interdisciplinary pathways and future prospects for the efficient clinical translation of micron-scale tablet technologies.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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