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The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity
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Qian WANG1, Fang JIA1, 2, Hongyu CUI3, Lixia ZHAO1, 2, *
China Dairy | 2026, (3) : 62 - 67
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China Dairy | 2026, (3): 62-67
• DISEASE PREVENTION •
The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity
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Qian WANG1, Fang JIA1, 2, Hongyu CUI3, Lixia ZHAO1, 2, *
Affiliations
  • 1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
  • 2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080
  • 3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
Published: 2026-03-25 doi: 10.12377/1671-4393.26.03.09
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[Objective]

To investigate the antibacterial activities of several antibiotics, hyaluronic acid (HA) alone, and HA combined with penicillin (PEN) against Staphylococcus aureus (S.aureus).

[Method]

The susceptibility of 1 standard strain and 9 clinical S.aureus strains isolated from dairy cattle to antimicrobial agents was evaluated using the double-dilution method and the micro-checkerboard method.

[Result]

The resistance rates of S.aureus to PEN, clindamycin and erythromycin were 90%, 80% and 40%, respectively. No methicillin-resistant strains were detected, and 40% of the strains showed inducible clindamycin resistance. The combination of HA and PEN exhibited either additive effect (FICI 0.5~1.0) or synergistic effect (FICI≤0.5) against all tested S.aureus strains.

[Conclusion]

The combination of HA and PEN can significantly reduce the effective minimal inhibitory concentration of both agents against S.aureus, which provides a new idea for the clinical treatment of drug-resistant S.aureus infections.

hyaluronic acid (HA)  /  penicillin (PEN)  /  Staphylococcus aureus (S.aureus)  /  minimal inhibitory concentration (MIC)
Qian WANG, Fang JIA, Hongyu CUI, Lixia ZHAO. The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity[J]. China Dairy, 2026 , (3) : 62 -67 . DOI: 10.12377/1671-4393.26.03.09
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Year 2026 volume Issue 3
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doi: 10.12377/1671-4393.26.03.09
  • Online Date：2026-08-20
  • Published：2026-03-25
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Affiliations
    1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
    2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080
    3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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