The regulation of nutritional immunity in dairy cows is a core aspect of ensuring herd health and enhancing production performance, and precision nutritional intervention has become an important direction in modern dairy farming. The rapid development of multi-omics technologies has provided effective tools for deciphering the complex regulatory mechanisms between nutrition and immunity in dairy cows. This paper systematically reviewed the application progress of multi-omics technologies in areas such as intestinal microecology-immune interactions, immunoregulatory mechanisms of key nutrients, nutritional stress responses, and the formulation of precision nutritional strategies. It further explored the central role of multi-omics technologies in advancing precision regulation of nutritional immunity in dairy cows, offering a reference for healthy dairy farming and high-quality industry development.

multi-omics technologies  /  dairy cows  /  nutritional immunity  /  precision regulation  /  regulatory mechanisms