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Research Progress on the Molecular Mechanisms and Applications of Nutrient Regulation of Immune Function in Dairy Ruminants
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Jianghong LEI1, Longfei SHI2, Qing WANG1, Yahui QI1, Min ZHAO1
China Dairy | 2026, (6) : 12 - 20
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China Dairy | 2026, (6): 12-20
• RUMINANT NUTRITION AND HEALTH •
Research Progress on the Molecular Mechanisms and Applications of Nutrient Regulation of Immune Function in Dairy Ruminants
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Jianghong LEI1, Longfei SHI2, Qing WANG1, Yahui QI1, Min ZHAO1
Affiliations
  • 1.Shaanxi Provincial Animal Health and Slaughter Management Station, Xi'an Shaanxi 710016
  • 2.Xi' an Animal Disease Prevention and Control Center, Xi'an Shaanxi 710054
Published: 2026-06-25 doi: 10.12377/1671-4393.26.06.02
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The immune function of dairy ruminants is a core factor in safeguarding their health status, production performance, and product quality. Nutrients, as the material basis for life activities, also serve as key signaling molecules regulating immune function. Through multiple pathways, such as directly acting on immune cells or indirectly modulating the gastrointestinal microbiota, nutrients profoundly influence the immune function of dairy ruminants. This paper systematically reviewed the direct regulatory mechanisms of key nutrients, such as amino acids and fatty acids, on immune cells, the indirect immune regulatory pathways of nutrients via the gastrointestinal microbiota and their metabolites, the role of nutrients in maintaining the intestinal physical and immune barrier, and the functions of nutrients in alleviating oxidative stress and regulating the balance of inflammatory cytokines. Furthermore, it summarized application strategies for immune enhancement, including the use of functional feed additives, precision nutrition, and phase-feeding. The aim is to provide a theoretical reference for formulating precision nutrition plans, enhancing immunity, and promoting healthy farming practices for dairy ruminants.

dairy ruminant  /  nutrient  /  immune function  /  gastrointestinal microbiota  /  intestinal barrier  /  inflammation regulation
Jianghong LEI, Longfei SHI, Qing WANG, Yahui QI, Min ZHAO. Research Progress on the Molecular Mechanisms and Applications of Nutrient Regulation of Immune Function in Dairy Ruminants[J]. China Dairy, 2026 , (6) : 12 -20 . DOI: 10.12377/1671-4393.26.06.02
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Year 2026 volume Issue 6
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doi: 10.12377/1671-4393.26.06.02
  • Online Date：2026-08-20
  • Published：2026-06-25
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    1.Shaanxi Provincial Animal Health and Slaughter Management Station, Xi'an Shaanxi 710016
    2.Xi' an Animal Disease Prevention and Control Center, Xi'an Shaanxi 710054
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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