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To explore the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) combined with amiodarone on patients with elderly heart failure (HF) complicated with ventricular arrhythmia (VA) and its impact on heart rate variability (HRV).
From January 2023 to January 2025, 220 patients with patients with elderly HF complicated with VA admitted to our hospital were prospectively selected and randomly separated into a control group (amiodarone) and an experimental group (rhBNP+amiodarone), with 110 patients in each group. The clinical outcomes, cardiac function, HRV indicators, serum N-terminal pro brain natriuretic peptide (NT-proBNP), QT interval dispersion (QTd), and adverse events were compared.
After treatment, the total effective rate in the experimental group was significantly higher than that in the control group (P<0.05). The experimental group had lower left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), NT-proBNP, and QTd than the control group (P<0.05), and higher left ventricular ejection fraction (LVEF), cardiac output (CO), RMSSD, SDNN, and PNN50 than the control group (P<0.05).
The combination of rhBNP and amiodarone has a conspicuous effect on patients with elderly HF complicated with VA. It can optimize cardiac function and HRV, improve electrophysiological stability, and has good safety.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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