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Current research on the regulatory role of the MAPKs signalling pathway in the osteogenesis-myogenesis process and the mechanisms of intervention by single-component traditional Chinese medicines
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Xin WANG1, Xi-ping CHAI2, Yu-meng ZHANG1, Tian-zhi MAO1, Hao-hao WU1, Hao-fan JIANG1
Chinese Journal of Clinical Pharmacology | 2026, 42(11) : 1602 - 1609
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Chinese Journal of Clinical Pharmacology | 2026, 42(11): 1602-1609
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Current research on the regulatory role of the MAPKs signalling pathway in the osteogenesis-myogenesis process and the mechanisms of intervention by single-component traditional Chinese medicines
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Xin WANG1, Xi-ping CHAI2, Yu-meng ZHANG1, Tian-zhi MAO1, Hao-hao WU1, Hao-fan JIANG1
Affiliations
  • 1.School of Clinical Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.The First Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
Published: 2026-06-17 doi: 10.13699/j.cnki.1001-6821.2026.11.017
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Objective

Sarcopenia-osteoporosis is an age-related syndrome caused by the coexistence of osteoporosis and sarcopenia, and it poses a serious threat to the health of the elderly population. The mitogen-activated protein kinases (MAPKs) signalling pathways, including extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK and c-Jun N-terminal kinase (JNK), regulate the proliferation, differentiation and apoptosis of skeletal muscle and bone tissue, and play a significant role in the development and progression of sarcopenia-osteoporosis. In recent years, various traditional Chinese medicine (TCM) constituents have demonstrated experimental value in modulating the MAPKs signalling pathway and influencing processes related to osteogenesis or muscle atrophy. This article reviews the regulatory effects of the MAPKs signalling pathway in osteogenesis and myogenesis, and summarises research progress on the use of various TCM monomers to intervene in sarcopenia-osteoporosis via this pathway, with the aim of providing new theoretical foundations and therapeutic strategies for the prevention and treatment of sarcopenia-osteoporosis.

traditional Chinese medicine single components  /  osteosarcopenia  /  osteogenesis  /  myogenesis  /  mitogen-activated protein kinases signaling pathway
Xin WANG, Xi-ping CHAI, Yu-meng ZHANG, Tian-zhi MAO, Hao-hao WU, Hao-fan JIANG. Current research on the regulatory role of the MAPKs signalling pathway in the osteogenesis-myogenesis process and the mechanisms of intervention by single-component traditional Chinese medicines[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (11) : 1602 -1609 . DOI: 10.13699/j.cnki.1001-6821.2026.11.017
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doi: 10.13699/j.cnki.1001-6821.2026.11.017
  • Receive Date：2026-01-12
  • Online Date：2026-08-06
  • Published：2026-06-17
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  • Received：2026-01-12
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Affiliations
    1.School of Clinical Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.The First Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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