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Heart failure (HF) refers to a clinical syndrome caused by structural or functional cardiac disorders that impair ventricular filling and/or ejection function, resulting in insufficient cardiac output to meet the metabolic demands of bodily tissues. Its clinical manifestations include congestion in the pulmonary and/or systemic circulation, as well as inadequate blood perfusion to organs and tissues. As the terminal stage of various cardiovascular diseases, HF ranks among the leading causes of death for urban and rural residents in China. microRNA (miRNA) is a class of endogenous non-coding single-stranded ribonucleic acids (RNAs) that regulate gene expression at the post-transcriptional level. They are involved in multiple pathological processes of HF, such as myocardial remodeling, cell death, energy metabolism and inflammatory immunity, thus exhibit potential as therapeutic targets for the disease. Traditional Chinese medicine (TCM), characterized by multi-targeted and multi-pathway actions, has shown unique advantages in the prevention and treatment of HF by modulating miRNAs. This article reviews the recent research status on miRNA-mediated regulation of HF and the mechanisms underlying TCM interventions, with the aim of providing insights for subsequent HF-related studies.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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