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Achondroplasia (ACH) is the most common hereditary short limb dwarfism, caused by functional acquired mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. In recent years, significant breakthroughs have been made in precision therapy targeting downstream pathways of FGFR3. Navepegritide (product name: YUVIWEL) is a long-acting C-type natriuretic peptide (CNP) prodrug that uses transient conjugation (TransCon) technology to couple CNP to PEG carrier molecules through a cleavable linker, achieving weekly subcutaneous administration. It was approved by the US Food and Drug Administration (FDA) in February 2026 to promote linear growth in children aged 2 years and above with non-closed epiphyseal plates and cartilage dysplasia. This article introduces the pharmacological properties, key clinical trial evidence, safety features, and clinical value of navepegritide, providing reference for clinical medication.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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