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Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring
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Xiao-qian LAN1, 2, Hong-yan ZHUANG1, 2, Shuang BAO1, 2, Yan-nan ZANG1, 2, Fei JIA1, 2, Meng-xi NIU1, 2, Peng-fei LI1, 2
Chinese Journal of Clinical Pharmacology | 2026, 42(9) : 1216 - 1220
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Chinese Journal of Clinical Pharmacology | 2026, 42(9): 1216-1220
• Clinical and Basic Bridging Research •
Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring
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Xiao-qian LAN1, 2, Hong-yan ZHUANG1, 2, Shuang BAO1, 2, Yan-nan ZANG1, 2, Fei JIA1, 2, Meng-xi NIU1, 2, Peng-fei LI1, 2
Affiliations
  • 1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders/National Clinical Research Center for Mental Disorders/National Center for Mental Disorders, Beijing Anding Hospital Afflicated to Capital Medical University, Beijing 100088, China
  • 2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100029, China
Published: 2026-05-17 doi: 10.13699/j.cnki.1001-6821.2026.09.003
Outline
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Objective

To investigate the influencing factors of the steady-state concentration/dose ratio (C/D) for milnacipran tablets based on therapeutic drug monitoring (TDM), with the goal of promoting individualized use of this medication.

Methods

Inpatients who underwent milnacipran TDM were included in this study. General information, including gender, age, body mass index (BMI) and serum creatinine levels were collected through the medical record system. Additionally, dosage and comedication data were recorded. The analysis of these data was conducted using SPSS 23.0.

Results

A total of 156 patients with steady-state concentrations determined by milnacipran TDM were included in the analysis. The steady-state concentration of milnacipran was found to be 95.52 (67.34, 126.97) ng·mL-1, C/D was 0.95 (0.71, 1.24) ng·mL-1·mg-1·d. Multiple linear regression analysis indicated that renal function statistically significantly influenced C/D (P<0.05). C/D ratio in patients with renal insufficiency and patients with normal insufficiency were 1.16 (0.79,1.50) and 0.92 (0.64,1.08) ng·mL-1·mg-1·d, with statisticaly significant difference (P<0.05).

Conclusion

The factors influencing milnacipran’s C/D are complex; therefore, for patients with renal insufficiency, regular monitoring of serum drug concentrations is recommended to ensure both safety and efficacy in its use.

milnacipran tablet  /  therapeutic drug monitoring  /  steady-state concentration  /  influencing factor  /  individualized medicine
Xiao-qian LAN, Hong-yan ZHUANG, Shuang BAO, Yan-nan ZANG, Fei JIA, Meng-xi NIU, Peng-fei LI. Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (9) : 1216 -1220 . DOI: 10.13699/j.cnki.1001-6821.2026.09.003
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Year 2026 volume 42 Issue 9
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Article Info
doi: 10.13699/j.cnki.1001-6821.2026.09.003
  • Receive Date：2026-03-12
  • Online Date：2026-08-06
  • Published：2026-05-17
Article Data
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History
  • Received：2026-03-12
Funding
Affiliations
    1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders/National Clinical Research Center for Mental Disorders/National Center for Mental Disorders, Beijing Anding Hospital Afflicated to Capital Medical University, Beijing 100088, China
    2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100029, China
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