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A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection
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Hong CUI1a, Jun LI1a, Liang-kun JIANG1b, Jia-xi MA1b, Bo WANG1b
Chinese Journal of Clinical Pharmacology | 2026, 42(7) : 1002 - 1004
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Chinese Journal of Clinical Pharmacology | 2026, 42(7): 1002-1004
• Medication Comment •
A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection
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Hong CUI1a, Jun LI1a, Liang-kun JIANG1b, Jia-xi MA1b, Bo WANG1b
Affiliations
  • 1a.Department of Infectious Diseases, First hospital of Peking University, Beijing 10034, China
  • 1b.Department of Emergency Medicine, First hospital of Peking University, Beijing 10034, China
Published: 2026-04-17 doi: 10.13699/j.cnki.1001-6821.2026.07.016
Outline
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Objective

To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase (NDM) secondary to complex intra-abdominal infection.

Methods

The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI, laboratory tests, changes in main inflammatory indicators (peripheral blood white blood cell count and procalcitonin), and drug sensitivity test results.

Results

After 13 days of treatment with eravacycline (50 mg, q12h) and colistimethate sodium (150 mg, q12h), the patient's condition and inflammatory indicators improved significantly, with no drug-related adverse reactions during hospitalization.

Conclusion

The combination is safe and effective for the above-mentioned sepsis, providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.

eravacycline hydrochloride for injection  /  colistimethate sodium for injection  /  carbapenem resistant Escherichia coli  /  sepsis
Hong CUI, Jun LI, Liang-kun JIANG, Jia-xi MA, Bo WANG. A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (7) : 1002 -1004 . DOI: 10.13699/j.cnki.1001-6821.2026.07.016
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Year 2026 volume 42 Issue 7
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Article Info
doi: 10.13699/j.cnki.1001-6821.2026.07.016
  • Receive Date：2026-01-27
  • Online Date：2026-08-06
  • Published：2026-04-17
Article Data
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History
  • Received：2026-01-27
Affiliations
    1a.Department of Infectious Diseases, First hospital of Peking University, Beijing 10034, China
    1b.Department of Emergency Medicine, First hospital of Peking University, Beijing 10034, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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