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Research status of rimegepant in migraine treatment
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Wen-hui LIU1, 2, Si-jie ZHANG1, 2, Yan WANG2, Si-qi OUYANG2, Yong-liang ZHU2, Dong-jun WAN2
Chinese Journal of Clinical Pharmacology | 2026, 42(6) : 885 - 892
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Chinese Journal of Clinical Pharmacology | 2026, 42(6): 885-892
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Research status of rimegepant in migraine treatment
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Wen-hui LIU1, 2, Si-jie ZHANG1, 2, Yan WANG2, Si-qi OUYANG2, Yong-liang ZHU2, Dong-jun WAN2
Affiliations
  • 1.Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou 730050, Gansu Province, China
Published: 2026-03-28 doi: 10.13699/j.cnki.1001-6821.2026.06.021
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Migraine is a highly disabling chronic disease that significantly affects patients’ quality of life. Conventional therapeutic drugs have limited application due to their insufficient efficacy, numerous contraindications and high risk of induce medication-overuse headache. With the in-depth research on the pathogenesis of migraine, the calcitonin gene-related peptide (CGRP) receptor has emerged as a noval target for the treatment and prevention of migraine. As a noval CGRP receptor antagonist, rimegepant was approved for marketing in China in 2024. Reserach has shown that rimegepant can simultaneously reduce the frequency of migraine attacks and the medication dosage in the acute phase. It is currently the first and only drug that can be used for both acute and preventive treatment of migraine, which makes up for the shortcomings of conventional therapeutic drugs. This article systematically reviews the research progress of rimegepant in the treatment of migraine, including its mechanism of action, pharmacokinetic characteristics, clinical trial, and safety evaluation, aiming to provide a evidence for the clinial treatment of migraine.

rimegepant  /  migraine  /  calcitonin gene-related peptide  /  calcitonin gene-related peptide receptor antagonist
Wen-hui LIU, Si-jie ZHANG, Yan WANG, Si-qi OUYANG, Yong-liang ZHU, Dong-jun WAN. Research status of rimegepant in migraine treatment[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (6) : 885 -892 . DOI: 10.13699/j.cnki.1001-6821.2026.06.021
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Article Info
doi: 10.13699/j.cnki.1001-6821.2026.06.021
  • Receive Date：2025-09-22
  • Online Date：2026-08-06
  • Published：2026-03-28
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  • Received：2025-09-22
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Affiliations
    1.Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou 730050, Gansu Province, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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