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Exposure-response (E-R) analyses aims to evaluate the quantitative relationship between the exposure and response of a drug at different doses. The E-R relationship is one of the core pieces of evidence supporting the assessment of the effectiveness and safety of new drugs, which is of great significance for selecting and optimizing dosage regimens, as well as determining dosing regimens for patients with different physiological, pathological, and genetic backgrounds. In recent years, the research and development of new drugs in China has continued to develop, and long-acting human glucagon-like peptide-1 receptor agonists have become one of the research hotspots. This article takes the weight management indication of semaglutide as an example to discuss the role of E-R analyses in dose selection during the research and development of new drugs, with the aim of promoting related researches in China.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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