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Research progress on the regulation of oxidative stress by single components of traditional chinese medicine in the prevention and treatment of gastrointestinal tumors
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Yong-ze GAO1, 2, Yu-jing ZHANG3, Liao-chan JIA3, Rong-rong YU4, Hai-xia SU5, Zi-jiao He1, Zhao-yuan FU1, 2, Jin-li ZHANG1
Chinese Journal of Clinical Pharmacology | 2026, 42(3) : 412 - 418
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Chinese Journal of Clinical Pharmacology | 2026, 42(3): 412-418
• Review •
Research progress on the regulation of oxidative stress by single components of traditional chinese medicine in the prevention and treatment of gastrointestinal tumors
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Yong-ze GAO1, 2, Yu-jing ZHANG3, Liao-chan JIA3, Rong-rong YU4, Hai-xia SU5, Zi-jiao He1, Zhao-yuan FU1, 2, Jin-li ZHANG1
Affiliations
  • 1.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, Gansu Province, China
  • 2.Gansu Provincial Clinical Research Center for Integrative Medicine in Gastroenterology, Lanzhou 730000, Gansu Province, China
  • 3.Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 4.Department of Gastroenterology, Gangu County People’s Hospital, Tianshui 741200, Gansu Province, China
  • 5.Department of Hepatology, the Second People’s Hospital of Lanzhou, Lanzhou 730000, Gansu Province, China
Published: 2026-02-17 doi: 10.13699/j.cnki.1001-6821.2026.03.018
Outline
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Gastrointestinal tumors, as clinically prevalent and highly malignant cancers, are closely associated with oxidative stress in their development. By inducing imbalances in intracellular reactive oxygen species (ROS) levels, oxidative stress promotes tumor cell proliferation, invasion, and drug resistance, making it a key target in contemporary cancer prevention and treatment research. In recent years, individual components of traditional Chinese medicine (TCM) have demonstrated significant potential in regulating oxidative stress due to their well-defined structures, diverse actions, and multi-target regulatory properties. This systematic review summarizes recent advances in how various TCM monomeric components inhibit gastrointestinal tumor cell proliferation and migration, induce apoptosis, and modulate the tumor microenvironment through antioxidant mechanisms. It focuses on analyzing key signaling pathways and molecular targets involved, such as nuclear factor E2-related factor 2 (Nrf2), mitogen-activated protein kinase (MAPK), and nuclear factor kappa-B (NF-κB). Integrating existing experimental evidence and partial clinical data, this review further reveals the potential application value of TCM monomers in the prevention and treatment of gastrointestinal tumors, while identifying current research challenges. It aims to provide theoretical foundations and directional references for basic research and new drug development in this field.

single-component Chinese herbal medicine  /  oxidative stress  /  gastrointestinal tumors
Yong-ze GAO, Yu-jing ZHANG, Liao-chan JIA, Rong-rong YU, Hai-xia SU, Zi-jiao He, Zhao-yuan FU, Jin-li ZHANG. Research progress on the regulation of oxidative stress by single components of traditional chinese medicine in the prevention and treatment of gastrointestinal tumors[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (3) : 412 -418 . DOI: 10.13699/j.cnki.1001-6821.2026.03.018
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Year 2026 volume 42 Issue 3
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Article Info
doi: 10.13699/j.cnki.1001-6821.2026.03.018
  • Receive Date：2025-12-18
  • Online Date：2026-08-06
  • Published：2026-02-17
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History
  • Received：2025-12-18
Funding
Affiliations
    1.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, Gansu Province, China
    2.Gansu Provincial Clinical Research Center for Integrative Medicine in Gastroenterology, Lanzhou 730000, Gansu Province, China
    3.Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    4.Department of Gastroenterology, Gangu County People’s Hospital, Tianshui 741200, Gansu Province, China
    5.Department of Hepatology, the Second People’s Hospital of Lanzhou, Lanzhou 730000, Gansu Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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