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A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam
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Ping LI1, Hong-li YU1, Wei XI2, Lu LIU1, Mei-xing YAN1, Chang LIU1
Chinese Journal of Clinical Pharmacology | 2026, 42(2) : 243 - 246
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Chinese Journal of Clinical Pharmacology | 2026, 42(2): 243-246
Adverse Drug Reactions
A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam
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Ping LI1, Hong-li YU1, Wei XI2, Lu LIU1, Mei-xing YAN1, Chang LIU1
Affiliations
  • 1.Dept. of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China
  • 2.Qingdao Institute for Food and Drug Control, Qingdao 266071, Shandong Province, China
Published: 2026-01-28 doi: 10.13699/j.cnki.1001-6821.2026.02.015
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A 20-month-old male infant was admitted to the department of infectious diseases of our hospital due to infectious fever and left cervical lymphadenitis. He received treatment with piperacillin sodium and tazobactam sodium for injection. After 7 consecutive days of medication (a total of 23 administrations) without adverse reactions, the infant suddenly developed symptoms of anaphylactic shock during the 24th administration, including irritability, incessant crying, pale complexion, cyanosis of the lips, cold extremities, and unmeasurable blood pressure. Medical staff immediately discontinued the infusion of piperacillin sodium and tazobactam sodium for injection and initiated rescue measures such as intramuscular injection of epinephrine. Eventually, the infant was successfully resuscitated. This case reminds medical personnel that the sensitization period of β-lactam antibiotics can last for several days or even months, which is concealed throughout the entire treatment course. The absence of adverse reactions during initial medication does not rule out subsequent risks. It is necessary to strengthen medical staff’s attention to medication monitoring during each administration to ensure the safety of pediatric medication.

piperacillin sodium and tazobactam sodium for injection  /  children  /  anaphylactic shock  /  adverse drug reactions  /  drug sensitization period
Ping LI, Hong-li YU, Wei XI, Lu LIU, Mei-xing YAN, Chang LIU. A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (2) : 243 -246 . DOI: 10.13699/j.cnki.1001-6821.2026.02.015
Year 2026 volume 42 Issue 2
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doi: 10.13699/j.cnki.1001-6821.2026.02.015
  • Receive Date:2026-01-22
  • Online Date:2026-08-06
  • Published:2026-01-28
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  • Received:2026-01-22
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Affiliations
    1.Dept. of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China
    2.Qingdao Institute for Food and Drug Control, Qingdao 266071, Shandong Province, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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