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To explore the efficacy of ceftazidime/avibactam (CAZ/AVI) combined with polymyxin in the treatment of carbapenem-resistant Gram-negative bacteria (CRO) pulmonary infections.
A total of 80 patients with CRO pulmonary infections admitted to our hospital from December 2019 to December 2024 were selected and divided into a control group (n=37) and a CAZ/AVI group (n=43) based on treatment methods. The control group received colistimethate sodium combined with meropenem, while the CAZ/AVI group received CAZ/AVI combined with colistimethate sodium. The clinical efficacy, bacterial clearance rate, and prognosis were compared between the two groups. Based on treatment efficacy, patients were classified into an effective group and an ineffective group, and logistic analysis was performed to identify factors influencing treatment outcomes in CRO pulmonary infections.
The clinical efficacy and bacterial clearance rate in the CAZ/AVI group were higher than those in the control group (P<0.05); there was no statistically significant difference in 28-day mortality between the two groups (P>0.05). The levels of WBC, CRP, PCT, TNF-α, IL-6, and IL-10 in the CAZ/AVI group were lower than those in the control group (P<0.05). In the effective group, age, APACHE Ⅱ score, SOFA score, and the proportion of patients receiving continuous renal replacement therapy (CRRT) were lower than those in the ineffective group, while treatment duration and the proportion receiving CAZ/AVI combined with polymyxin were higher (P<0.05). Logistic analysis indicated that APACHE Ⅱ score, SOFA score, CRRT, treatment duration, and CAZ/AVI combined with polymyxin were influencing factors for treatment outcomes in CRO pulmonary infections (P<0.05).
CAZ/AVI combined with polymyxin shows significant efficacy in the treatment of CRO pulmonary infections.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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