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Rheumatoid arthritis is a multifactorial autoimmune disease with an unknown etiology. In recent years, an increasing number of research findings have indicated that matrix metalloproteinase-3 (MMP-3) is most closely related to the pathogenesis of rheumatoid arthritis and is a key enzyme involved in joint destruction in patients with rheumatoid arthritis. A large number of studies have shown that traditional Chinese medicine can play a role in the prevention and treatment of rheumatoid arthritis by regulating the expression of MMP-3 in rheumatoid arthritis. This article explores the possible molecular mechanisms by which MMP-3 causes rheumatoid arthritis and systematically summarizes the literature on the regulation of MMP-3 by traditional Chinese medicine in the prevention and treatment of rheumatoid arthritis in recent years, with the aim of providing a theoretical basis for the research and clinical treatment of rheumatoid arthritis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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