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Brexpiprazole, a novel atypical antipsychotic drug, has therapeutic effects in the treatment and prevention of relapse of schizophrenia. It exerts its efficacy through partial agonism of dopamine D2 receptor and 5-hydroxytryptamine receptor 1A (5-HT1A), as well as antagonism of 5-HT2A receptor. In terms of pharmacokinetics, it features high oral bioavailability, a long half-life, and minimal influence of food on its absorption. Multiple clinical trials have confirmed its effectiveness in the acute treatment (2-4mg every day) and maintenance treatment (1-4mg every day) of schizophrenia. Regarding safety, common adverse reactions include akathisia and weight gain, with a relatively low risk of metabolic abnormalities. No systematic review of brexpiprazole has been published in China. This article conducts a systematic search for the first time and reviews it from aspects such as its mechanism of action, pharmacokinetic characteristics, clinical efficacy, and safety, providing a reference for rational clinical use.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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