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Signal transducer and activator of transcription 3 (Stat3), as a crucial transcription factor, plays a core regulatory role in regulating the cell cycle and various cellular processes such as proliferation, survival, differentiation, and inflammatory responses. Aberrant activation of Stat3 is closely related to the occurrence and development of many tumors. Meanwhile, the activity and stability of Stat3 are influenced by its post-translational modifications, including phosphorylation, acetylation, methylation, etc., among which phosphorylation is one of the most critical regulatory mechanisms. Under pathological and physiological stimuli, phosphorylation modifications can alter the structure of Stat3 in different cells, thereby determining specific gene programs. This process leads to the activation of Stat3 and promotes tumor cell proliferation, etc. This article focuses on the phosphorylation modification of Stat3, systematically elaborating on the regulatory mechanisms of its main phosphorylation sites (tyrosine 705 site and serine 727 site), as well as its roles in tumor cell cycle regulation, apoptosis inhibition, angiogenesis, invasion and metastasis, and tumor microenvironment remodeling. At the same time, it explores tumor treatment strategies targeting Stat3 phosphorylation, providing theoretical references for tumor mechanism research and clinical treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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