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A 55 years old female patient was given propofol medium and long chain fat emulsion injection once, during the operation due to traumatic brain injury (TBI), with no documented adverse drug reactions (ADRs). Postoperative cerebral edema was treated with propofol injectable emulsion sedation to lower intracranial pressure. One day after medication initiation, the patient developed oliguria, darkened urine, elevated creatine kinase, elevated transaminases and electrocardiogram (ECG) changes. The patient responded poorly to fluid resuscitation and hepatoprotective therapy, leading to a presumptive diagnosis of propofol infusion syndrome (PRIS). Three days later withdrawal of propofol symptomatic treatment were administered. The patient’s symptoms and laboratory tests improved, but later death due to heart arrest. This case serves as a reminder that clinicians should be vigilant about the cumulative dose and infusion duration of propofol when treating critically ill patients. The absence of ADRs with previous use don’t entirely preclude the risk of subsequent administration. Early recognition of PRIS is critical. Once patients experience symptoms such as unexplained creatine kinase elevation and ECG changes, early diagnosis, timely drug withdrawal and symptomatic treatment measures such as hemofiltration should be taken to ensure medication safety.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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