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Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism
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Wei-wei ZHANG1a, 2, 3, Kang SHE1b, Min YANG1b, Zi-ning WANG1a
Chinese Journal of Clinical Pharmacology | 2025, 41(24) : 3530 - 3535
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Chinese Journal of Clinical Pharmacology | 2025, 41(24): 3530-3535
• Medication Comment •
Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism
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Wei-wei ZHANG1a, 2, 3, Kang SHE1b, Min YANG1b, Zi-ning WANG1a
Affiliations
  • 1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
  • 1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China
  • 2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
  • 3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
Published: 2025-12-28 doi: 10.13699/j.cnki.1001-6821.2025.24.013
Outline
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Objective

To provide anticoagulation recommendations and optimize pharmacotherapy for a patient with lower extremity arterial embolism following aortic valve replacement by integrating pharmacogenomics and drug-drug interactions with medication education.

Methods

A clinical pharmacist participated in the anticoagulation therapy and medication monitoring for a patient who underwent emergency surgery due to lower extremity arterial embolism after mechanical aortic valve replacement. Based on an analysis of the patient′s individual condition and clinical characteristics, and with reference to guidelines and evidence-based literature, the clinical pharmacist guided the perioperative anticoagulation regimen. Factors influencing the effect of warfarin were also analyzed to optimize its dosage.

Results

The patient′s lower extremity arterial embolism improved, and the patient was discharged with favorable follow-up outcomes.

Conclusion

This case provides a reference for clinical pharmacists in managing anticoagulation therapy for patients with lower extremity arterial embolism after mechanical heart valve replacement.

warfarin  /  mechanical prosthetic aortic valve replacement  /  lower extremity arterial embolism  /  pharmaceutical care
Wei-wei ZHANG, Kang SHE, Min YANG, Zi-ning WANG. Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (24) : 3530 -3535 . DOI: 10.13699/j.cnki.1001-6821.2025.24.013
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.24.013
  • Receive Date：2025-10-15
  • Online Date：2026-08-05
  • Published：2025-12-28
Article Data
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History
  • Received：2025-10-15
Affiliations
    1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
    1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China
    2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
    3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
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https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.24.013
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