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To study the possible mechanism and related signaling pathway of cell senescence in hypertensive nephropathy with the help of bioinformatics.
The microarray data GSE37455 was downloaded from the gene expression database, and the data was merged with R software to remove the batch effect, so as to obtain differentially expressed genes. Cell aging genes were obtained from the CellAge database, and differential genes related to cell aging were obtained through R package “ggVennDiagram”. Gene interaction network string database was imported to obtain protein protein interaction (PPI) network map, and Cytoscape3.8.0 software was used to mine core differential genes. The function and pathway of core differential genes were analyzed by gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG) and gene set enrichment analysis (GSEA).
A total of 41 differential genes were obtained, including 32 up-regulated genes and 9 down-regulated genes. Four differential genes related to cell senescence were obtained after intersection. The core differential gene-activated transcription factor 3(ATF3) was obtained by PPI analysis and Cytoscape treatment. GSEA analysis showed that cell senescence might play a role in hypertensive nephropathy through the thermogenesis of mitochondrial uncoupling protein 1 and the signal transduction of type Ⅰ interferon response (TYPE-Ⅰ-IFN).
Cellular senescence may play a role in hypertensive nephropathy through pathways such as mitochondrial uncoupling protein-1 thermogenesis and TYPE-Ⅰ-IFN signaling, which provides a therapeutic target for the study of hypertensive nephropathy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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