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The safety and efficacy of tranexamic acid in the perioperative period of burn patients remain controversial. This study aimed to investigate the safety and efficacy of tranexamic acid in perioperative burn patients.
A systematic search was conducted in Pubmed, Embase, Cochrane Library, China national know-ledge infrastructure (CNKI), Wanfang, and other databases up to March 1, 2025, for studies on the use of tranexamic acid in perioperative burn care. The primary outcomes included total perioperative blood loss, perioperative blood transfusion events, operative time, all-cause mortality, and incidence of adverse events. Meta-analysis was performed using RevMan 5.4.1, with risk of bias assessed using Cochrane’s ROB 2 tool and Robins-1 tool.
Seven studies were included, comprising a total of 465 cases (218 in the tranexamic acid intervention group and 247 in the control group). The findings demonstrated that the total perioperative blood loss in the tranexamic acid group was significantly lower than in the control group [MD=-165.01, 95% confidence interval (CI) (-210.13 to -119.89), P<0.001]. Additionally, tranexamic acid reduced operative time [MD=-8.32, 95% CI (-14.55 to -2.09), P=0.009] and perioperative blood transfusion events (OR=0.26, 95% CI 0.15-0.44, P<0.001), without increasing all-cause mortality (OR=0.67, 95% CI 0.33 to 1.36, P=0.27).
Tranexamic acid is effective in reducing total perioperative blood loss, shortening operative time, and decreasing the risk of perioperative blood transfusion events in burn patients, without increasing all-cause mortality. Thus, tranexamic acid can serve as a valuable adjunct in perioperative management for burn patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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