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Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus. Due to its insidious onset and unclear pathogenesis, DKD is easy to progress to end-stage renal disease. Endoplasmic reticulum is the main site of protein synthesis and processing in the body. When affected by adverse factors of the body, endoplasmic reticulum stress (ERS) will be triggered, resulting in the accumulation of misfolded or unfolded proteins, resulting in imbalance of the internal environment. Studies have shown that ERS is involved in the core pathogenesis of DKD, and the renal tissue lesions caused by DKD can be effectively alleviated by regulating ERS. This article focuses on the experimental studies on the intervention of ERS with traditional Chinese medicine and its compound in the prevention and treatment of DKD, in order to provide new ideas and reference for clinical treatment of DKD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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