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A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen
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MENG JIN1, Yu-ming CHENG1, 2, Rui-jie ZHUO1, 2, Yan-ran DENG1, 2, Hui LIU1, Hui-jing ZHANG1, 2, Le MA1, 2, Cheng GAN3, Mu-ge CHELI4, Bei-bei XU1
Chinese Journal of Clinical Pharmacology | 2025, 41(19) : 2833 - 2840
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Chinese Journal of Clinical Pharmacology | 2025, 41(19): 2833-2840
• Drug Evaluation and Administration •
A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen
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MENG JIN1, Yu-ming CHENG1, 2, Rui-jie ZHUO1, 2, Yan-ran DENG1, 2, Hui LIU1, Hui-jing ZHANG1, 2, Le MA1, 2, Cheng GAN3, Mu-ge CHELI4, Bei-bei XU1
Affiliations
  • 1.Medical Informatics Center, Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China
  • 2.School of Public Health, Peking University, Beijing 100191, China
  • 3.Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China
  • 4.Medical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010110, China
Published: 2025-10-17 doi: 10.13699/j.cnki.1001-6821.2025.19.021
Outline
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Objective

This systematic review and Meta-analysis compared the efficacy and safety of dexibuprofen with ibuprofen across diverse clinical settings.

Methods

A comprehensive literature search was performed across multiple databases (PubMed, Embase, Web of Science, Scopus, Cochrane Library, and CNKI) to identify all relevant clinical trials comparing dexibuprofen and ibuprofen. Statistical analyses were conducted using RevMan 5.4.

Results

A Meta-analysis incorporating 21 randomized controlled trials demonstrated that dexibuprofen showed no statistically significant differences in efficacy compared to ibuprofen at full-dose (RR=1.02, 95% CI: 0.99-1.05), 70% doses (RR=0.92, 95% CI: 0.72-1.17), or 50% doses (RR=0.99, 95% CI: 0.82-1.19). Subgroup analyses indicated comparable efficacy between dexibuprofen and ibuprofen for both adult analgesia (RR=1.09, 95% CI: 0.97-1.23) and pediatric antipyresis (RR=1.01, 95% CI: 0.98-1.04). Regarding safety, full-dose dexibuprofen showed a lower risk of adverse events compared to ibuprofen (RR=0.76, 95% CI: 0.58-1.00).

Conclusion

Dexibuprofen demonstrates comparable efficacy to ibuprofen, exhibits good dose-sparing characteristics in the fields of analgesia and antipyresis. Furthermore, it exhibits superior safety at equivalent doses, making it suitable for patient populations requiring reduced drug exposure or those at risk of gastrointestinal adverse reactions.

dexibuprofen  /  ibuprofen  /  Meta-analysis  /  efficacy  /  safety
MENG JIN, Yu-ming CHENG, Rui-jie ZHUO, Yan-ran DENG, Hui LIU, Hui-jing ZHANG, Le MA, Cheng GAN, Mu-ge CHELI, Bei-bei XU. A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (19) : 2833 -2840 . DOI: 10.13699/j.cnki.1001-6821.2025.19.021
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Year 2025 volume 41 Issue 19
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.19.021
  • Receive Date：2025-07-02
  • Online Date：2026-08-05
  • Published：2025-10-17
Article Data
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History
  • Received：2025-07-02
Affiliations
    1.Medical Informatics Center, Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China
    2.School of Public Health, Peking University, Beijing 100191, China
    3.Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China
    4.Medical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010110, China
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