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With China’s transition into an aging society, Parkinson’s disease (PD) has emerged as the second most prevalent neurodegenerative disorder threatening the health of the elderly population. However, there is still a lack of ideal clinical drugs that can effectively treat PD or halt its progression. Mitochondrial dysfunction is one of the key pathogenic mechanisms underlying PD, involving abnormalities in energy metabolism, mitophagy, oxidative stress, calcium homeostasis, mitochondrial dynamics and apoptosis. In recent years, traditional Chinese medicine (TCM) has demonstrated promising efficacy in treating PD by targeting mitochondrial function. Based on the critical role of mitochondrial dysfunction in PD pathogenesis, this article focuses on the research progress of TCM monomers and compound formulations in intervening PD by regulating pathways related to mitochondrial dysfunction. The aim is to provide a theoretical foundation and novel insights for further research into TCM-based mitochondrial-targeted therapies for PD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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