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Research status of PI3K / Akt signaling pathway in precancerous lesions of gastric cancer and traditional Chinese medicine intervention
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Peng-cheng DOU1, Sheng CHANG2, Rui-ping SONG3, Jiao-jiao ZUO1, Zhuang-zhuang FENG4, Xin-yi CHEN5, Xiao-long WANG1, Jin SHU3
Chinese Journal of Clinical Pharmacology | 2025, 41(18) : 2679 - 2684
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Chinese Journal of Clinical Pharmacology | 2025, 41(18): 2679-2684
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Research status of PI3K / Akt signaling pathway in precancerous lesions of gastric cancer and traditional Chinese medicine intervention
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Peng-cheng DOU1, Sheng CHANG2, Rui-ping SONG3, Jiao-jiao ZUO1, Zhuang-zhuang FENG4, Xin-yi CHEN5, Xiao-long WANG1, Jin SHU3
Affiliations
  • 1.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
  • 2.Continuing Education College, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
  • 3.Spleen and Stomach Disease Diagnosis and Treatment Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
  • 4.Clinical Teaching Department, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
  • 5.Drug Clinical Trial Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
Published: 2025-09-28 doi: 10.13699/j.cnki.1001-6821.2025.18.019
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The high morbidity and mortality of gastric cancer seriously affect and threaten the public's life and health. Precancerous lesions of gastric cancer (PLGC) is a key stage in the process of gastric mucosal carcinogenesis, and it is also a "golden turning point" before the formation of gastric cancer. Early and effective intervention has become an important way and research focus for the prevention and control of gastric cancer. Phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) signaling pathway is involved in a variety of biological processes such as inflammatory response, angiogenesis, autophagy level and apoptosis. Studies have confirmed that this pathway is abnormally activated in PLGC and can promote the malignant progression of the disease to gastric cancer by regulating a variety of pathways, which can be used as a potential target and effective way for the prevention and treatment of PLGC. In recent years, traditional Chinese medicine has achieved many research results in delaying or even reversing PLGC by targeting the PI3K/Akt signaling pathway. Based on the PI3K/Akt signaling pathway, this paper systematically expounds the role of this signaling pathway in PLGC and the research progress of traditional Chinese medicine intervention, in order to provide reference for the clinical treatment of this disease and drug development and application.

traditional Chinese medicine  /  precancerous lesions of gastric cancer  /  phosphatidylinositol-3 kinase/protein kinase B signaling pathway
Peng-cheng DOU, Sheng CHANG, Rui-ping SONG, Jiao-jiao ZUO, Zhuang-zhuang FENG, Xin-yi CHEN, Xiao-long WANG, Jin SHU. Research status of PI3K / Akt signaling pathway in precancerous lesions of gastric cancer and traditional Chinese medicine intervention[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (18) : 2679 -2684 . DOI: 10.13699/j.cnki.1001-6821.2025.18.019
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.18.019
  • Receive Date：2024-11-18
  • Online Date：2026-08-05
  • Published：2025-09-28
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  • Received：2024-11-18
Funding
Affiliations
    1.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
    2.Continuing Education College, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
    3.Spleen and Stomach Disease Diagnosis and Treatment Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
    4.Clinical Teaching Department, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
    5.Drug Clinical Trial Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
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红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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