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Research progress on SGLT2 inhibitors regulating mitochondrial homeostasis to protect cardiomyocytes
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Yuan-hao LONG1, Guo-liang ZOU2
Chinese Journal of Clinical Pharmacology | 2025, 41(20) : 2962 - 2968
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Chinese Journal of Clinical Pharmacology | 2025, 41(20): 2962-2968
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Research progress on SGLT2 inhibitors regulating mitochondrial homeostasis to protect cardiomyocytes
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Yuan-hao LONG1, Guo-liang ZOU2
Affiliations
  • 1.Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
  • 2.Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Published: 2025-10-28 doi: 10.13699/j.cnki.1001-6821.2025.20.019
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors, as a new class of oral antidiabetic drugs, have gained attention in the cardiovascular and metabolic fields due to their non-dependent hypoglycemic effects and cardioprotective effects. Studies have confirmed that these drugs protect myocardial cells by reconstructing the mitochondrial metabolic network in cardiomyocytes. They are widely used in patients with cardiovascular diseases and show significant efficacy. This article integrates recent research findings, systematically reviewing the mechanisms of myocardial cell protection under multidimensional regulation of mitochondrial metabolism by SGLT2 inhibitors. It expands the theoretical support for their use in cardiovascular therapy and provides references for related research directions.

sodium-glucose cotransporter 2 inhibitor  /  mitochondria  /  mitochondrial autophagy  /  oxidative stress  /  AMP-activated protein kinase
Yuan-hao LONG, Guo-liang ZOU. Research progress on SGLT2 inhibitors regulating mitochondrial homeostasis to protect cardiomyocytes[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (20) : 2962 -2968 . DOI: 10.13699/j.cnki.1001-6821.2025.20.019
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.20.019
  • Receive Date：2025-06-13
  • Online Date：2026-08-05
  • Published：2025-10-28
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  • Received：2025-06-13
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Affiliations
    1.Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
    2.Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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