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Research progress on the prevention and treatment of cerebral ischemia and related diseases by apigenin
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Qian-qian LIU1, 2, Ke WANG3, Yue WANG1, 2, Huai-yu LIU1, 2, Ping LAN1, 2, Shuang ZHANG1, 2, Zhi HE1, 2, 3
Chinese Journal of Clinical Pharmacology | 2025, 41(20) : 2955 - 2961
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Chinese Journal of Clinical Pharmacology | 2025, 41(20): 2955-2961
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Research progress on the prevention and treatment of cerebral ischemia and related diseases by apigenin
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Qian-qian LIU1, 2, Ke WANG3, Yue WANG1, 2, Huai-yu LIU1, 2, Ping LAN1, 2, Shuang ZHANG1, 2, Zhi HE1, 2, 3
Affiliations
  • 1.Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, Hubei Province, China
  • 2.School of Health Medicine, China Three Gorges University, Yichang 443002, Hubei Province, China
  • 3.School of Medicine, Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Published: 2025-10-28 doi: 10.13699/j.cnki.1001-6821.2025.00.018
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Cerebral ischemia is a common neurological disease worldwide, with complex pathophysiological mechanisms, which seriously affects the quality of life of patients after the onset of the disease. Currently, cerebral ischemia is mainly treated with drugs and surgery, and its lethality and disability rate are still at a high level due to the limitation of time window and neurological irreversibility. Therefore, finding a safe and effective drug is crucial for the treatment of cerebral ischaemia. apigenin is a naturally occurring flavonoid with a variety of biological activities, such as combating oxidative stress, anti-inflammatory and neuroprotective effects. In recent years, an increasing number of studies have demonstrated the potential therapeutic role of apigenin in cerebral ischaemia. This paper describes the mechanisms of apigenin in preventing and treating cerebral ischaemia, including anti-oxidative stress, attenuating neuroinflammation, regulating apoptosis and promoting neuroregeneration. In addition, this paper discusses the prospects and challenges for the clinical application of apigenin in the treatment of cerebral ischaemia.

apigenin  /  cerebral ischemia  /  neuroprotection
Qian-qian LIU, Ke WANG, Yue WANG, Huai-yu LIU, Ping LAN, Shuang ZHANG, Zhi HE. Research progress on the prevention and treatment of cerebral ischemia and related diseases by apigenin[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (20) : 2955 -2961 . DOI: 10.13699/j.cnki.1001-6821.2025.00.018
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.00.018
  • Receive Date：2025-06-13
  • Online Date：2026-08-05
  • Published：2025-10-28
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  • Received：2025-06-13
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Affiliations
    1.Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, Hubei Province, China
    2.School of Health Medicine, China Three Gorges University, Yichang 443002, Hubei Province, China
    3.School of Medicine, Jiaxing University, Jiaxing 314000, Zhejiang Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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