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To systematically screen potential antioxidant targets for the treatment of Alzheimer’s disease (AD) based on network pharmacology strategy.
Firstly, the structure-data file (SDF) of the antioxidant compound library was converted into the standard simplified molecular input line entry system (SMILES) molecular structure format usingrational discovery kit (RDKit), and then the potential targets of antioxidant compounds were predicted using the SwissTargetPrediction platform. After the obtained targets were analyzed with the differentially expressed genes of AD, a protein interaction network (PPI network) was constructed, and the functional interaction relationship was mined based on the STRING database. Further, the "compound-disease target-signaling pathway" network diagram was established with the help of Cytoscape software to screen key therapeutic targets. Finally, the core targets were annotated with Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis using the DAVID database.
Finally, 10 core targets with potential anti-Alzheimer’s disease effects were screened. Among them, the top three key nodes in degree value were heat shock protein 90α family class B member 1 (HSP90AB1), catenin β1 (CTNNB1) and proto-oncogene tyrosine protein kinase (SRC). Enrichment analysis suggested that these core targets may be mainly involved in the pathogenesis and intervention of Alzheimer’s disease through calcium signaling pathway and phosphatidyqinositol-3 kinase/protein kinase B (PI3K-Akt) signaling pathway, and had important therapeutic potential.
This study systematically identified the core antioxidant targets and key pathways for the treatment of Alzheimer’s disease from the perspective of network pharmacology, providing theoretical support for further research on antioxidant drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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