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Polycystic ovary syndrome (PCOS) is a common reproductive and endocrine metabolic disorder in women of childbearing age. Its pathological mechanisms are complex and diverse, involving insulin resistance, hyperandrogenemia, oxidative stress damage, and disorders of glucose and lipid metabolism. Studies have found that the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is involved in regulating the apoptosis and autophagy of ovarian granulosa cells (GCs). Traditional Chinese medicine precisely regulates the expression of proteins related to the PI3K/Akt pathway through multiple components and multiple targets, inhibits abnormal apoptosis and excessive autophagy of GCs, thereby significantly improving ovarian function and metabolic disorders, alleviating clinical symptoms of PCOS patients and delaying disease progression. This review explores the regulatory role of the PI3K/Akt signaling pathway in PCOS and analyzes the potential mechanisms of targeted intervention of PCOS by traditional Chinese medicine. Through a comprehensive analysis of existing literature, the research progress of traditional Chinese medicine monomers and their compound preparations in improving clinical symptoms of PCOS is summarized, aiming to provide scientific theoretical support for the rational clinical application of traditional Chinese medicine in the prevention and treatment of PCOS and to provide new research ideas for the development of new therapeutic drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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