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Research status of JNK-mediated signaling network regulation of Alzheimer’s disease
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Ting CHEN1, Ping YANG2, Xue-mei WANG2, Xi-xiang LI2, Shuai-yin LI1
Chinese Journal of Clinical Pharmacology | 2025, 41(9) : 1335 - 1340
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Chinese Journal of Clinical Pharmacology | 2025, 41(9): 1335-1340
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Research status of JNK-mediated signaling network regulation of Alzheimer’s disease
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Ting CHEN1, Ping YANG2, Xue-mei WANG2, Xi-xiang LI2, Shuai-yin LI1
Affiliations
  • 1.College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Faculty of Pharmacy, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
Published: 2025-05-17 doi: 10.13699/j.cnki.1001-6821.2025.09.024
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Neuroinflammation, neuronal damage, and signal fragmentation between neurons make cognitive dysfunction is the main pathological basis of Alzheimer’s disease (AD). It is characterized by significant cognitive and sensory impairment caused by irreversible progressive neurological dysfunction. It is unclear how molecular changes associated with AD affect information processing in neuronal circuits and translate into cognitive dysfunction. c-Jun N-terminal kinase (JNK) plays a key regulatory role in the AD process. In this paper, we review the pathological process of AD research progress of JNK-targeted inhibitory drugs to provide a basis for the treatment of AD diseases and the development and application of targeted drugs.

Alzheimer’s disease  /  c-Jun N-terminal kinase signaling pathway  /  neuroinflammation  /  amyloid β-protein  /  tau protein
Ting CHEN, Ping YANG, Xue-mei WANG, Xi-xiang LI, Shuai-yin LI. Research status of JNK-mediated signaling network regulation of Alzheimer’s disease[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (9) : 1335 -1340 . DOI: 10.13699/j.cnki.1001-6821.2025.09.024
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doi: 10.13699/j.cnki.1001-6821.2025.09.024
  • Receive Date：2024-12-17
  • Online Date：2026-08-04
  • Published：2025-05-17
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  • Received：2024-12-17
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Affiliations
    1.College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Faculty of Pharmacy, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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