Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways

Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways

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Ding-cai MA^1a^,^1b, Mao-mao WANG^1a^,^1b, Zhe WANG^1a^,^1b, Yu-gui ZHANG^1a^,^1b, Ting LIU^1a^,^1b, Fei-yun GAO^1a^,^1b, Yan-jun WANG^1a^,^1b, Zhuan-hong ZHANG^1a^,^1b, Yue-feng LI^1b

Chinese Journal of Clinical Pharmacology | 2025, 41(8) : 1191 - 1195

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Chinese Journal of Clinical Pharmacology | 2025, 41(8): 1191-1195

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Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways

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Ding-cai MA^1a^,^1b, Mao-mao WANG^1a^,^1b, Zhe WANG^1a^,^1b, Yu-gui ZHANG^1a^,^1b, Ting LIU^1a^,^1b, Fei-yun GAO^1a^,^1b, Yan-jun WANG^1a^,^1b, Zhuan-hong ZHANG^1a^,^1b, Yue-feng LI^1b

Affiliations

^1a.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

^1b.Scientific Researsh and Experimental Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Published: 2025-04-28 doi: 10.13699/j.cnki.1001-6821.2025.08.025

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Abstract

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Surgery, chemoradiotherapy are the conventional methods of clinical treatment of tumor, due to adverse reactions, drug resistance and other problems, the prognosis and survival are poor. Due to its characteristics of stable action with little toxic side effects and multi-channel and multi-target comprehensive regulation, traditional Chinese medicine has been widely concerned and recognized in anti-tumor. Autophagy and apoptosis are two ways of programmed cell death, and the interaction between autophagy and apoptosis is crucial to the overall fate of cancer cells. The balance between autophagy and apoptosis contains the theory of Yin and Yang in traditional Chinese medicine, and has become an effective strategy for clinical treatment of cancer. This study summarized the mechanism of the signaling pathway involved in the regulation of autophagy and apoptosis balance and thus effectively inhibited the pathological process of tumors, in order to provide pharmacological basis and scientific reference for the development and clinical application of traditional Chinese medicine anti-tumor drugs.

Key words

traditional Chinese medicine / signaling pathway / autophagy and apoptosis balance / anti-tumor

Cite this Article

Ding-cai MA, Mao-mao WANG, Zhe WANG, Yu-gui ZHANG, Ting LIU, Fei-yun GAO, Yan-jun WANG, Zhuan-hong ZHANG, Yue-feng LI. Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (8) : 1191 -1195 . DOI: 10.13699/j.cnki.1001-6821.2025.08.025

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Year 2025 volume 41 Issue 8

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Article Info

doi: 10.13699/j.cnki.1001-6821.2025.08.025

Receive Date：2024-10-17
Online Date：2026-08-04
Published：2025-04-28

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Received：2024-10-17

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Affiliations

^1a.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

^1b.Scientific Researsh and Experimental Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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