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To observe the clinical efficacy and safety of ferulic acid piperazine tablets combined with continuous renal replacement therapy in the treatment of children with acute renal failure.
Children with acute renal failure were randomly divided into control group and treatment group. Both groups were given basic treatment, based on which, the control group was given continuous renal replacement therapy; the treatment group was given piperazine ferulate tablets 100 mg per time, orally, tid, on the basis of control group. Two groups were treated for 2 weeks. The clinical efficacy, renal function, levels of renal injury markers and safety were compared between the two groups.
Treatment group was enrolled 85 cases, 2 cases dropped out, and 83 cases were finally included in the statistical analysis. Control group was enrolled 84 cases, 3 cases dropped out, and 81 cases were finally included in the statistical analysis. After treatment, the total effective rates of treatment and control groups were 92.77% (77 cases/83 cases) and 81.48% (66 cases / 81 cases) with statistically significant difference (P<0.05). After treatment, the serum creatinine levels of treatment and control groups were (120.35±17.12) and (148.12±20.03) μmoL·L-1; the blood urea nitrogen levels were (12.29±2.14) and (15.64±3.01) μmoL·L-1; the β2-microglobulin levels were (1.87±0.25) and (2.14±0.39) mg·L-1; the 24-h urinary protein quantification were (0.94±0.31) and (1.24±0.47) g·24 h-1; N-acetyl-β-D-glucosidase contents were (17.03±2.98) and (20.36±3.51) U·L-1; the renal injury molecule 1 contents were (1.62±0.27) and (2.09±0.32) μg·L-1; the neutrophil gelatinase-associated lipid transport protein contents were (50.36±8.13) and (59.23±10.14) μg·L-1, respectively, and the differences were all statistically significant (all P<0.05). The adverse drug reactions of treatment group were nausea, vomiting and abdominal distension, while those in the control group were dizziness, nausea and vomiting. The total incidences of adverse drug reactions in the treatment and control groups were 7.23% and 4.94% without significant difference (P>0.05).
Ferulic acid piperazine tablets combined with continuous renal replacement therapy have definitive clinical efficacy in the treatment of children with acute renal failure, which can significantly improve the renal function of children, reduce renal injury, without increasing the incidence of adverse drug reactions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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