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Research status of ncRNA-Nrf2-NF-κB signaling pathway and anti-atherosclerotic drugs for regulating blood lipids
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An HUANG1a, 1b, 1c, Xiao-dan MO1a, 1b, 1c, Xiu-fen YANG1a, 1b, 1c
Chinese Journal of Clinical Pharmacology | 2025, 41(7) : 1020 - 1025
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Chinese Journal of Clinical Pharmacology | 2025, 41(7): 1020-1025
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Research status of ncRNA-Nrf2-NF-κB signaling pathway and anti-atherosclerotic drugs for regulating blood lipids
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An HUANG1a, 1b, 1c, Xiao-dan MO1a, 1b, 1c, Xiu-fen YANG1a, 1b, 1c
Affiliations
  • 1a.College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
  • 1b.Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
  • 1c.Key Laboratory of Traditional Chinese Medicine Neurometabolism and Immunopharmacology of Guangxi Education Department, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
Published: 2025-04-17 doi: 10.13699/j.cnki.1001-6821.2025.07.022
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Non-coding RNA (ncRNA), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor κB (NF-κB) signaling pathways are involved in the interaction between ncRNA, Nrf2 and NF-κB, the mechanism that regulates blood lipids and anti-atherosclerosis. ncRNA, including microRNA (miRNA), small interfering RNA (siRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), are potential drug targets in the study of lipid regulation and anti-atherosclerosis drugs. Nrf2-NF-κB signaling pathway is an important pathway for regulating oxidative stress and inflammatory responses, regulating lipid levels and reducing the risk of cardiovascular diseases such as atherosclerosis. In addition, ncRNA, as an important regulatory molecule, can regulate oxidative stress and inflammation by regulating Nrf2-NF-κB signaling pathway, thus play an important role in regulating blood lipids and anti-atherosclerosis. This paper reviews the current research and development status of ncRNA-Nrf2-NF-κB signaling pathway in the field of lipid-regulating anti-atherosclerotic drugs, including drugs currently on the market and drugs under development, in order to provide new ideas and directions for the prevention and treatment of cardiovascular diseases such as atherosclerosis.

non-coding RNA  /  nuclear factor erythroid 2-related fator 2-nuclear factor κB signaling pathway  /  lipid-regulating  /  anti-atherosclerotic drugs
An HUANG, Xiao-dan MO, Xiu-fen YANG. Research status of ncRNA-Nrf2-NF-κB signaling pathway and anti-atherosclerotic drugs for regulating blood lipids[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (7) : 1020 -1025 . DOI: 10.13699/j.cnki.1001-6821.2025.07.022
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doi: 10.13699/j.cnki.1001-6821.2025.07.022
  • Receive Date：2024-10-13
  • Online Date：2026-08-04
  • Published：2025-04-17
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  • Received：2024-10-13
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Affiliations
    1a.College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
    1b.Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
    1c.Key Laboratory of Traditional Chinese Medicine Neurometabolism and Immunopharmacology of Guangxi Education Department, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
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