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To observe the protective effect of resveratrol on kidney of diabetic rats through lipid metabolism pathway.
The SD rats were randomly divided into control group, model group and experimental -L, -M, -H groups. The control group was fed with normal feed, while the other four groups were all based on high-fat and high-sugar feed feeding + intraperitoneal injection of streptozotocin to establish diabetic rat models. After successful modeling, the control group and the model group were given the same amount of normal saline, while the experimental-L, -M, -H groups were given 5, 25, 50 mg·kg-1 concentration of resveratrol once a day, and were given continuous gavage for 10 weeks. Kidney function levels [cystatin C (Cys-C), serum creatinine (SCr), blood urea nitrogen (BUN)]were determined by enzyme-linked immunosorbent assay. The expressions of peroxissome proliferator-activated receptor γ (PPARγ), fatty acid- binding protein (FABP1), peroxisomal acyl-coenzyme A oxidase 1 (ACOX) 2 and ACOX1 were detected by Western blot.
The Cys-C levels of experimental -M, -H groups, control group, model group were (1.85±0.15), (1.39±0.11), (0.78±0.11) and (2.42±0.32) mg·L-1; SCr levels were (55.74±7.02), (48.15±6.97), (32.41±4.22) and (68.15±8.48) μmol·L-1; BUN levels were (10.37±1.02), (9.41±0.87), (7.12±1.12) and (14.48±2.45) mmol·L-1; the relative expression levels of PPARγ protein were 0.74±0.08, 0.92±0.10, 1.22±0.15 and 0.39±0.05; the relative expression levels of FABP1 protein were 0.64±0.08, 0.81±0.07, 0.98±0.09 and 0.30±0.05; the relative expression levels of ACOX2 protein were 0.59±0.06, 0.72±0.07, 0.85±0.13 and 0.27±0.05; the relative expression levels of ACOX1 protein were 0.58±0.06, 0.67±0.05, 0.78±0.06 and 0.24±0.03. The differences of above indexes were statistically significant between the experimental-M, -H groups and control group and the model group (all P<0.05).
Resveratrol may play a protective role on kidney of diabetic rats by regulating lipid metabolism pathway.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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