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Osteoarthritis (OA) is a prevalent chronic degenerative condition in clinical settings, marked by a prolonged disease course and unfavorable prognosis. It imposes a substantial burden on both society and affected families. Chondrocyte apoptosis is a typical pathological manifestation of OA cartilage degeneration, and autophagy is a biological process in which cells are induced by various stressors to activate the lysosomal degradation pathway, selectively degrade and remove the organelles and protein aggregates damaged by internal aging, so as to maintain their own homeostasis. The mammalian target of rapamycin (mTOR)-related signaling pathway is an important regulatory pathway for autophagy. The mTOR signaling pathway is involved in the physiological and pathological processes such as apoptosis and autophagy of OA chondrocytes, and is one of the important targets for the study of OA at home and abroad. Based on the relevant literature in recent years, this paper summarizes the specific role of mTOR in the development of OA and the mechanism of action of traditional Chinese medicine in regulating the mTOR signaling pathway in the prevention and treatment of OA.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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