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Pyroptosis plays an important role in the development of rheumatoid arthritis (RA) and the molecules involved in the pyroptosis pathway can influence the course of RA. Therefore, inhibition of pyroptosis may be an effective therapeutic strategy to slow down the development of RA. In this paper, we systematically reviewed the relationship between pyroptosis and RA, explored the mechanism of pyroptosis in RA from three aspects: nucleotide oligomerisation structural domain-like receptor protein 3 inflammatory vesicles, Gasdermin family of proteins and inflammatory cytokines, and revealed how the relevant molecules in the pyroptosis pathway contribute to inflammatory responses and intercellular signalling, thereby exacerbating the progression of RA. The aim of this review is to provide a theoretical basis for the study of the pathological mechanisms of RA and the development of therapeutic drugs for RA that target the inhibition of pyroptosis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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