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Correlation of G protein-coupled estrogen receptor and the metabolic syndrome
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Yu-ting MA1, Sheng-yu WEN1, Zhu-fang SHEN1, 2, Shuai-nan LIU1, 2, Cai-na LI1, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(11) : 1641 - 1645
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Chinese Journal of Clinical Pharmacology | 2025, 41(11): 1641-1645
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Correlation of G protein-coupled estrogen receptor and the metabolic syndrome
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Yu-ting MA1, Sheng-yu WEN1, Zhu-fang SHEN1, 2, Shuai-nan LIU1, 2, Cai-na LI1, 2
Affiliations
  • 1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2.Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2025-06-17 doi: 10.13699/j.cnki.1001-6821.2025.11.025
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G protein-coupled estrogen receptor (GPER) is expressed in a variety of tissues and cells, mainly in the inner cell membrane (endoplasmic reticulum and Golgi apparatus), and also localized in the nucleus. Studies have shown that the GPER signaling pathway is involved in regulating the development of metabolic syndrome (MS), and the lack of GPER expression significantly induces MS features such as obesity, disorders of glucose-lipid metabolism, and hypertension in mice, whereas GPER agonists can improve glucose-lipid metabolism. In this paper, the correlation between GPER and various features of MS is reviewed, with the aim to providing research ideas for the development of anti-MS drugs based on GPER.

metabolic syndrome  /  estrogen  /  G protein-coupled estrogen receptor
马玉婷, 文晟昱, 申竹芳, 刘率男, 李彩娜. G蛋白偶联雌激素受体与代谢综合征的相关性研究. 中国临床药理学杂志, 2025 , 41 (11) : 1641 -1645 . DOI: 10.13699/j.cnki.1001-6821.2025.11.025
Yu-ting MA, Sheng-yu WEN, Zhu-fang SHEN, Shuai-nan LIU, Cai-na LI. Correlation of G protein-coupled estrogen receptor and the metabolic syndrome[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (11) : 1641 -1645 . DOI: 10.13699/j.cnki.1001-6821.2025.11.025
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Year 2025 volume 41 Issue 11
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doi: 10.13699/j.cnki.1001-6821.2025.11.025
  • Receive Date：2024-12-25
  • Online Date：2026-08-04
  • Published：2025-06-17
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  • Received：2024-12-25
Funding
Affiliations
    1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2.Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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