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Correlation of G protein-coupled estrogen receptor and the metabolic syndrome
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Yu-ting MA1, Sheng-yu WEN1, Zhu-fang SHEN1, 2, Shuai-nan LIU1, 2, Cai-na LI1, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(11) : 1641 - 1645
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Chinese Journal of Clinical Pharmacology | 2025, 41(11): 1641-1645
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Correlation of G protein-coupled estrogen receptor and the metabolic syndrome
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Yu-ting MA1, Sheng-yu WEN1, Zhu-fang SHEN1, 2, Shuai-nan LIU1, 2, Cai-na LI1, 2
Affiliations
  • 1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2.Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2025-06-17 doi: 10.13699/j.cnki.1001-6821.2025.11.025
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G protein-coupled estrogen receptor (GPER) is expressed in a variety of tissues and cells, mainly in the inner cell membrane (endoplasmic reticulum and Golgi apparatus), and also localized in the nucleus. Studies have shown that the GPER signaling pathway is involved in regulating the development of metabolic syndrome (MS), and the lack of GPER expression significantly induces MS features such as obesity, disorders of glucose-lipid metabolism, and hypertension in mice, whereas GPER agonists can improve glucose-lipid metabolism. In this paper, the correlation between GPER and various features of MS is reviewed, with the aim to providing research ideas for the development of anti-MS drugs based on GPER.

metabolic syndrome  /  estrogen  /  G protein-coupled estrogen receptor
Yu-ting MA, Sheng-yu WEN, Zhu-fang SHEN, Shuai-nan LIU, Cai-na LI. Correlation of G protein-coupled estrogen receptor and the metabolic syndrome[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (11) : 1641 -1645 . DOI: 10.13699/j.cnki.1001-6821.2025.11.025
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doi: 10.13699/j.cnki.1001-6821.2025.11.025
  • Receive Date：2024-12-25
  • Online Date：2026-08-04
  • Published：2025-06-17
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  • Received：2024-12-25
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Affiliations
    1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2.Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China
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