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Research status of the effect of adipokines on diabetic cardiomyopathy
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Zhen-ya WU1, Yi-fan WANG1, Hong-mei MA1, Sheng-nan LIU1, Li-juan WANG1, Fei-ru WANG3, Zi-qiong WANG1, Hui-hui TANG1, Wen YANG1, Jin-yang WANG2
Chinese Journal of Clinical Pharmacology | 2025, 41(7) : 1032 - 1037
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Chinese Journal of Clinical Pharmacology | 2025, 41(7): 1032-1037
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Research status of the effect of adipokines on diabetic cardiomyopathy
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Zhen-ya WU1, Yi-fan WANG1, Hong-mei MA1, Sheng-nan LIU1, Li-juan WANG1, Fei-ru WANG3, Zi-qiong WANG1, Hui-hui TANG1, Wen YANG1, Jin-yang WANG2
Affiliations
  • 1.First School of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Cadre Endocrinology, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
  • 3.First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China
Published: 2025-04-17 doi: 10.13699/j.cnki.1001-6821.2025.07.024
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Obesity is a ‘key’ component that contributes to the further development of type 2 diabetes mellitus (T2DM). Adipose tissue releases adipokines that act on the cardiovascular system in an endocrine and paracrine manner, different adipokines have different effects. Pro-inflammatory adipokines exacerbate inflammatory responses and oxidative stress in cardiomyocytes, leading to myocardial hypertrophy and interstitial fibrosis, inducing heart failure. Anti-inflammatory adipokines protect against high glucose-induced vascular endothelial dysfunction and delay the development of cardiovascular complications in T2DM by inhibiting endoplasmic reticulum stress, oxidative stress and increasing nitric oxide production. Balancing the roles played by pro-inflammatory and anti-inflammatory adipokines in diabetic cardiomyopathy (DCM) is crucial. In this paper, we will study the effect of obesity-associated adipokines in DCM, summarise novel glucose-lowering drugs in the clinic that can both reduce body weight and benefit the heart, and provide a theoretical basis for preventing and treating the development of obesity-combined DCM.

diabetic cardiomyopathy  /  obesity  /  adipokines  /  therapeutic drug
Zhen-ya WU, Yi-fan WANG, Hong-mei MA, Sheng-nan LIU, Li-juan WANG, Fei-ru WANG, Zi-qiong WANG, Hui-hui TANG, Wen YANG, Jin-yang WANG. Research status of the effect of adipokines on diabetic cardiomyopathy[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (7) : 1032 -1037 . DOI: 10.13699/j.cnki.1001-6821.2025.07.024
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doi: 10.13699/j.cnki.1001-6821.2025.07.024
  • Receive Date：2024-10-29
  • Online Date：2026-08-04
  • Published：2025-04-17
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  • Received：2024-10-29
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Affiliations
    1.First School of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Department of Cadre Endocrinology, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
    3.First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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