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Development of non-clinical pharmacodynamic evaluation of IgA nephropathy
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Zeng-ping XU, Qing-li WANG, Mei-ling CHEN, Hong-mei GUANG
Chinese Journal of Clinical Pharmacology | 2025, 41(6) : 895 - 900
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Chinese Journal of Clinical Pharmacology | 2025, 41(6): 895-900
Drug Evaluation and Administration
Development of non-clinical pharmacodynamic evaluation of IgA nephropathy
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Zeng-ping XU, Qing-li WANG, Mei-ling CHEN, Hong-mei GUANG
Affiliations
  • Centre for Drug Evaluation, National Medical Products Administration, Beijing 100076, China
Published: 2025-03-28 doi: 10.13699/j.cnki.1001-6821.2025.06.028
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Immunoglobulin A (IgA) nephropathy is a common primary glomerular disease. Because the pathogenesis of IgA nephropathy is still unclear, it is difficult to study the pharmacodynamics of IgA nephropathy through an ideal non-clinical pharmacodynamic model. In order to provide non-clinical efficacy research and development reference for IgA nephropathy drugs, the non-clinical pharmacodynamic research and development of IgA nephropathy drugs, non-clinical efficacy model, clinical and non-clinical efficacy evaluation index of overseas marketed products in recent years are introduced in this paper.

immunoglobulin A nephropathy  /  non-clinical pharmacodynamic model  /  effectiveness evaluation
Zeng-ping XU, Qing-li WANG, Mei-ling CHEN, Hong-mei GUANG. Development of non-clinical pharmacodynamic evaluation of IgA nephropathy[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (6) : 895 -900 . DOI: 10.13699/j.cnki.1001-6821.2025.06.028
Year 2025 volume 41 Issue 6
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doi: 10.13699/j.cnki.1001-6821.2025.06.028
  • Receive Date:2024-10-15
  • Online Date:2026-08-04
  • Published:2025-03-28
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  • Received:2024-10-15
Affiliations
    Centre for Drug Evaluation, National Medical Products Administration, Beijing 100076, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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