To observe the anesthetic effects and safety of remazolam injection combined with alfentanil injection in the treatment of patients with hysteroscopic surgery.

Patients scheduled for hysteroscopic surgery were randomly divided into control group and treatment group. The control group received intravenous 1.5-2.0 mg·kg^-1 propofol + 7-10 μg·kg^-1 alfentanil for anesthetic induction, during the surgery, continuously infused with 4-12 mg·kg^-1·h^-1 propofol + 0.05-0.20 μg·kg^-1·h^-1 remifentanil for anesthesia maintenance. The treatment group was given intravenous 0.3-0.5 mg·kg^-1 remimazolam + 7-10 μg·kg^-1 alfentanil for anesthetic induction, during the surgery, received 0.5-1.0 mg·kg^-1·h^-1remazolam+ 0.05-0.20 μg·kg^-1·h^-1 remifentanil for anesthesia maintenance. The hemodynamics, analgesic effects, cognitive function and safety were compared between the two groups.

Control group were enrolled 52 cases, 3 cases dropped out, and 49 cases were finally included in the statistical analysis. Treatment group were enrolled 53 cases, 4 cases dropped out, and 49 cases were finally included in the statistical analysis. At the end of the surgery, the mean arterial pressure of treatment and control groups were (73.98±7.41) and (60.10±6.84) mmHg, the heart rates were (68.43±7.32) and (63.92±7.36) beat·min^-1, the differences of above index were statistically significant between two groups (all P<0.05). One hour after operation, the visual analogue scale scores of treatment and control groups were (3.08±0.49) and (3.86±0.61) points, the mini-mental state examination scores were (22.65±2.41) and (18.24±2.38) points, the differences were statistically significant (all P<0.05). The adverse drug reactions of treatment group were nausea, while those in the control group were bradycardia, hypotension, respiratory depression and nausea. The total incidences of adverse drug reactions in the treatment and control groups were 2.04% and 14.29%, with statistically significant difference (P<0.05).

Remazolam injection combined with alfentanil injection can help to maintain hemodynamics of patients with hysteroscopic surgery, reduce the risk of postoperative pain and cognitive impairment, with good safety.